NTP finds common indoor pollutant absorbed and distributed in rodents
The common indoor pollutant alpha-pinene is systemically absorbed and distributed to mammary glands of rodents following inhalation exposure, according to scientists in the NIEHS Division of the National Toxicology Program (DNTP). The research may be relevant to human health following exposure to alpha-pinene.
Alpha-pinene comes from the oil of coniferous trees and is a major component in turpentine. Human exposure to alpha-pinene can occur via the lumber industry, use of turpentine, and use of consumer products that contain alpha-pinene as a fragrance or flavoring ingredient. However, there is little data regarding the potential hazard from exposure to alpha-pinene.
Male and female rats and mice were exposed to alpha-pinene by whole body inhalation, at concentrations relevant to human exposures. After exposure, levels of alpha-pinene and its potential reactive metabolite, alpha-pinene oxide, were assessed in blood and mammary glands to estimate toxicokinetic parameters.
The researchers found alpha-pinene and alpha-pinene oxide in the blood and mammary glands and that levels increased with the exposure concentration. Generally, alpha-pinene and metabolite levels were higher in rats than in mice and in mammary glands than in blood. The findings may be important in providing context and relating animal toxicity findings to human exposures. (VP)
Citation: Waidyanatha S, Hackett M, Black SR, Stout MD, Fennell TR, Silinski MR, Watson SL, Licause J, Robinson VG, Sparrow B, Fernando RA, Cooper S, Rider CV. 2021. Toxicokinetic evaluation of the common indoor air pollutant, alpha-pinene, and its potential reactive metabolite, alpha-pinene oxide, following inhalation exposure in rodents. Toxicol Appl Pharmacol 418:115496.