Pesticides identified for possible cancer hazard reviews
Researchers in the Division of the National Toxicology Program (DNTP) successfully employed a two-tiered method for identifying and prioritizing candidate pesticides for possible cancer hazard assessments. Their approach included an initial search for registered pesticides that were classified according to the U.S. Environmental Protection Agency (EPA) as possible, suggestive, or likely human carcinogens. They also searched for pesticides that were widely used and had not undergone a hazard assessment in the past five years. Using the EPA database and available resources, the researchers found a total of 18 pesticides that met these requirements.
In the second part of their process, the investigators conducted a literature search, screen, and evidence mapping of cancer epidemiology studies with pesticide-specific data on the 18 compounds. These studies were also published after each pesticide’s last EPA carcinogenicity assessment. The scientists found that for 16 of the 18 pesticides, human cancers data had been published after the initial carcinogenicity evaluation. Of these 16, eight had three or more studies published on at least one type of cancer. This protocol could serve as a tool for identifying pesticides that could potentially cause cancer. (NA)
Citation: Schwingl PJ, Lunn RM, Mehta SS. 2021. A tiered approach to prioritizing registered pesticides for potential cancer hazard evaluations: implications for decision making. Environ Health 20(1):13.