Bisphenol AF is absorbed rapidly in rodents
Researchers from the National Toxicology Program (NTP) and their collaborators found that orally administered bisphenol AF (BPAF), which is structurally similar to bisphenol A (BPA), can be rapidly absorbed in rodents. The research provides insight into the potential effects of BPAF on animal and human health.
BPAF is an industrial chemical used to produce synthetic rubber and plastic. Studies have reported that BPAF is toxic to aquatic organisms and could cause hormones imbalances in rats. To provide further safety data for BPAF, NTP researchers conducted toxicity testing of BPAF in rodents. The absorption, distribution, metabolism, and excretion data that they published previously showed BPAF could be deposited in tissue and eliminated from the body. This study provided further comprehensive toxicokinetic data for BPAF.
The researchers observed that BPAF was rapidly absorbed in both rats and mice, with maximum plasma concentrations reached within a couple of hours after oral administration. Following absorption, BPAF was extensively conjugated and rapidly removed, with low bioavailability in both species. Similar results were found in both male and female rats and mice. The researchers concluded that the deposition pattern of BPAF resembles that of well-researched BPA. (QX)
Citation: Waidyanatha S, Black SR, Aillon K, Collins B, Patel PR, Riordan F, Sutherland V, Robinson VG, Fernando R, Fennell TR 2019. Toxicokinetics and bioavailability of bisphenol AF following oral administration in rodents: a dose, species, and sex comparison. Toxicol Appl Pharmacol 373:39–47.