NTP chemists show body treats BPS similar to other bisphenols
National Toxicology Program (NTP) chemists have conducted a full evaluation of the absorption, distribution, metabolism, and excretion of bisphenol S (BPS) in rats and mice. BPS and its derivatives are being used increasingly in consumer products as an alternative to bisphenol A (BPA). The impact that the large-scale replacement of BPA by other analogues, such as BPS, has on public health is of ongoing interest to the NTP. As part of this effort, how BPS is processed in both humans and rodent models following exposure is necessary for putting toxicological findings into the greater context of human exposure.
This evaluation provided a comparison of clearance of BPS and derivatives in human, rat, and mouse liver cells. Generally, clearance in rodent hepatocytes was faster than in human hepatocytes in vitro. Following oral exposure of radiolabeled BPS in rats and mice, main excretion was found to be via the kidneys. Excretion via the kidneys became saturated with an increasing dose, indicated by the higher dose excreted in feces. Retention of BPS-derived species in tissues was low. The data also indicated that BPS is metabolized mainly via glucuronidation and sulfonation. These observations are consistent with previous reports on other members of the bisphenol class. (AD)
Citation: Waidyanatha S, Black SR, Snyder RW, Yueh YL, Sutherland V, Patel PR, Watson SL, Fennell TR. 2018. Disposition and metabolism of the bisphenol analogue, bisphenol S, in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans. Toxicol Appl Pharmacol 351:32–45.