NTP scientists offer recommendations for dietary supplement safety
National Toxicology Program scientists and their collaborators reviewed current approaches for conducting absorption, distribution, metabolism, and excretion (ADME) studies of botanical dietary supplements, identified knowledge gaps, and presented recommendations for advancing the field.
An estimated 18 percent of United States residents consume botanical dietary supplements, but safety and toxicity data for these compounds are rarely available. ADME data can help scientists design toxicity studies, clarify potential botanical-drug interactions, and extrapolate animal toxicity data for human safety assessment. The authors used a case study with Ginkgo biloba extract to highlight challenges of studying botanicals and to demonstrate the usefulness of ADME data in botanical dietary supplement safety assessment.
The authors identified four key areas scientists should keep in mind when generating data for assessing the safety of a botanical dietary supplements: phytochemical characterization; robust ADME study design; investigation of human relevance; and in vitro or in vivo studies to identify pharmacokinetic botanical-drug interactions and active or marker constituents. (FW)
Citation: Waidyanatha S, Ryan K, Roe AL, Jia W, Paine MF, Ferguson S, Gurley BJ, Welch K, Chow MSS, Devito M, Rider C. 2018. Follow that botanical: challenges and recommendations for assessing absorption, distribution, metabolism and excretion of botanical dietary supplements. Food Chem Toxicol 121:194–202.