NTP scientists collaborate on risk assessment
Researchers from the National Toxicology Program, the U.S. Environmental Protection Agency, and several other national and international organizations, have collaborated on the Next Generation (NextGen) of Risk Assessment project, a multiyear effort to incorporate emerging data streams into environmental health risk assessments. Standardizing the use of new technologies in risk assessment will improve public health, through rapid identification of chemical exposures of concern, and characterization of potential risks and susceptibilities.
The researchers discussed how new resources, such as public health databases and high-throughput data, can aid in regulatory decision-making. These resources account for several factors that are not captured in traditional toxicity testing, including human variability, mechanism of action, and biomarkers of exposure. Case studies of well-characterized human toxins, such as benzene and ozone, were used to validate the use of alternative data in risk assessment.
The NextGen framework moves toward practical application of emerging technologies in risk assessment, although several challenges remain. The quick evolution of this field has led to the publication of inadequate studies, due to lagging acceptance and implementation of best practices in experimental design and data reporting. In addition, more work must be done to accurately correlate events identified by high-throughput assays with adverse health outcomes in humans. (GH)
Citation: Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS. 2016. The Next Generation of Risk Assessment multiyear study — highlights of findings, applications to risk assessment, and future directions. Environ Health Perspect; doi:10.1289/EHP233 [Online 19 April 2016].