New resource for studying developing mouse vasculature
A research team led by scientists at the National Toxicology Program created a comprehensive histology atlas of the developing mouse blood and lymphatic vasculature using hematoxylin and eosin and immunohistochemical stain. The atlas specifically focused on the hepatobiliary vascular system in mice embryos 11.5-18.5 days old and in the early postnatal period. The project originally began as a reliable way to identify normal hepatobiliary vascular development, but the work helped scientists point out an anatomical structure that had been misidentified in previous publications.
The atlas displays low- and high-magnification color images of the developing embryonic mouse hepatobiliary vascular system and an accompanying 3-dimensional (3D) video representation of the E18.5 mouse venous vasculature. The findings were based on the CD1 mouse strain, and correctly identified the portal sinus, a structure that was previously misinterpreted as the ductus venosus. The authors noted that developmental differences and abnormalities might be observed when comparing different strains. The digital images and 3D video can be viewed online at https://niehsimages.epl-inc.com/, with the username “ToxPathLiver” and password “embryolivers.” To view the video, select Projects, then Embryo Hepatobiliary Vascular System, click on the brain symbol associated with the “3D Video,” and open Primary Slide Attachments. (RA)
Citation: Swartley OM, Foley JF, Livingston DP 3rd, Cullen JM, Elmore SA. 2016. Histology atlas of the developing mouse hepatobiliary hemolymphatic vascular system with emphasis on embryonic days 11.5-18.5 and early postnatal development. Toxicol Pathol; doi:10.1177/0192623316630836 [Online 8 March 2016].