skip navigation
Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

Environmental Factor, February 2015

/
Whole Issue PDF
This issue's PDF is still being created and should be available 3-5 business days after the first of the month. Please check back in a few days.

Distinguished lecture examines prenatal exposures in child development

By Robin Arnette

Frederica Perera

"In a recent year, more pesticides were used in New York City to deal with cockroaches and other pests, than were used in agriculture for the entire state of New York," Perera said. "If you include all the other environmental exposures, material hardship, and psychosocial stress due to poverty, as well as less access to healthy food, the result is major health disparities." (Photo courtesy of Steve McCaw)

Linda Birnbaum, Ph.D.

Birnbaum and Perera share a passion for environmental health. (Photo courtesy of Steve McCaw)

  • Darryl Zeldin, Ph.D.
    1/3

    NIEHS Scientific Director Darryl Zeldin, M.D., asked if the children’s cohort had accompanying genetic data and whether future environmental exposure studies would include a genetic component. (Photo courtesy of Steve McCaw)

  • Richard Paules, Ph.D., Jack Bishop, Ph.D. and Cindy Lawler, Ph.D.
    2/3

    Perera’s talk brought current and former NIEHS scientists together. From left, Richard Paules, Ph.D., acting chief of the NTP Biomolecular Screening Branch; Jack Bishop, Ph.D., retired NTP geneticist; and Cindy Lawler, Ph.D., chief of the NIEHS Division of Extramural Research and Training (DERT) Genes, Environment, and Health Branch. (Photo courtesy of Steve McCaw)

  • Jerrold Heindel, Ph.D.
    3/3

    Jerrold Heindel, Ph.D., a health scientist administrator in DERT, has administered many NIEHS grants focused on understanding the fetal window of susceptibility. (Photo courtesy of Steve McCaw)

A large body of research has presented compelling evidence that the environmental exposures a pregnant woman experiences affect her unborn child. Work done by Frederica Perera, Ph.D., Dr.P.H., her colleagues at the Columbia Center for Children’s Environmental Health (CCCEH), and others suggest that those exposures may also negatively impact the child’s health into his or her adolescent years and beyond.

As a molecular epidemiologist and environmental health scientist at Columbia University in New York City, Perera focuses on preventing childhood neurodevelopmental impairment, asthma, obesity, and cancer through early identification of environmental risk factors. NIEHS and National Toxicology Program (NTP) Director Linda Birnbaum, Ph.D., invited Perera to the Distinguished Lecture Seminar Series, to talk about her research.

Perera’s Jan. 13 lecture, "The Fetal Window of Susceptibility: Using Molecular Epidemiology to Understand the Role of Prenatal Environmental Exposures on Child Health and Development,” shared data from the CCCEH Birth Cohort Study (see sidebar).

Environmental stress

Perera set the stage for her lecture by asking the audience to visualize the complex processes that take place simultaneously during human fetal brain development — this highly choreographed process is at the heart of fetal susceptibility. Perera said a high rate of cell proliferation puts DNA at risk of damage from chemicals and oxygen radicals. Moreover, because the fetus has immature defense mechanisms, it is less able to clear toxicants. While these strains weigh heavily on the fetus, the mother also has to deal with environmental pressures during pregnancy.

Download Media Player:

"We have to realize there is high vulnerability of the fetus to co-exposures to environmental toxicants and psychosocial stresses experienced by the mother," Perera said. "These stressors frequently occur in underserved populations."

Several previous studies from various scientists, such as former NIEHS Director Kenneth Olden, Ph.D., found that low-income communities are disproportionally exposed to toxic air pollutants. Perera corroborated this point by citing several sources of pollutants in New York City. For example, most of the Metropolitan Transit Association diesel bus depots and sewage waste transfer stations are located in northern Manhattan, namely Harlem, and the south Bronx. According to Perera, many of the buildings in these areas are under-maintained and are heavily treated with pesticides. As a consequence, their residents experience high rates of pesticide exposure, in addition to airborne pollutants.

Toxicants and neuronal development

Perera said that since burning fossil fuel was suspected of contributing to many of the health problems the community faces, the cohort study targeted a major class of pollutants from combustion of diesel, gasoline, coal, oil, and natural gas — the polycyclic aromatic hydrocarbons (PAHs).

In addition to air pollution from combustion by-products, fossil fuel is the source of petrochemicals from which many billions of pounds of chemical products are derived. These include phthalates, pesticides, and materials treated with polybrominated diphenyl ether (PBDE) flame retardants. Petrochemicals are found in a number of consumer products, ranging from fragrances, plastics, and furniture to electronic equipment and shampoo.

Perera and her CCCEH colleagues conducted studies that focused on these toxicants. Their prenatal exposure findings suggest:

  • Prenatal PAH exposure is associated with lower IQ scores and neurobehavioral problems, including ADHD, when children were assessed from early childhood through pre-adolescence.
  • Children of mothers who had higher exposure to phthalates during pregnancy had significant IQ decreases when assessed at age 7.
  • Newborns with high cord plasma levels of PBDEs showed a consistent pattern of having decreased IQ when assessed at ages 4 and 6.

When science changes policy

Perera concluded her talk with the reforms in New York City that resulted, in part, from the Center’s research. They include limits on idling trucks and buses, policies on traffic congestion, and legislation to restrict the use of toxic pesticides in public housing.

"These are beautiful examples of how environmental research can make the world better," Birnbaum said.




"Exposome workshop uncovers the ..." - previous story Previous story Next story next story - "NIEHS researchers determine new ..."
February 2015 Cover Page

Back to top Back to top