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This Month in EHP

By Eddy Ball
August 2009

EHP: TwitterThe August issue of Environmental Health Perspectives (EHP) ( explores "The Future of Toxicity Testing" with a Focus article on the Tox21 partnership of the National Toxicology Program, the NIH Chemical Genomics Center and U.S. Environmental Protection Agency that seeks to transform toxicology testing for the 21st century. Addressing the "Ethics of Observational Research," a Spheres of Influence feature examines the ethical issues of the investigator's role in child observational research.

EHP August 2009In a Health Policy commentary, University of California, Berkeley Program in Green Chemistry and Chemicals Policy researchers Michael Wilson, Ph.D., and Megan Schwarzman, M.D., examine U.S. chemicals policy and offer arguments for rebuilding the foundation of policy to advance new science, green chemistry and environmental health.

Highlights from the issue include the following studies:

  • Racial Differences in Paraoxonase-1 - Offering further evidence to support the hypothesis that racial differences in cardiovascular disease risk may be partly explained by differences in paroxonase-1, a lactonase/hydrolase that associates with high-density lipoprotein (HDL) particles
  • Half-Lives of Persistent Organic Pollutants in Human Populations - Applying a multi-individual pharmacokinetic model for clarifying the interpretation of human elimination half-lives of persistent organic pollutants derived from cross-sectional trend data and estimating these values using data collected in post-ban situations
  • Age of Greatest Susceptibility to Lead Exposure - Using modeling data to demonstrate that blood lead (BPb) levels at six years of age may have a stronger impact on cognitive and behavioral development than BPb at two years of age and suggesting that BPb be included in diagnostic evaluations of school-age children with cognitive or behavioral problems
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