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Upcoming Distinguished Lecture Features Mitchell Lazar

By Eddy Ball
February 2008

Mitchell Lazar, M.D., Ph.D.
Distinguished Lecturer Mitchell Lazar (Photo courtesy of Vesselina Panteva and the University of Pennsylvania)

The 2007-2008 NIEHS Distinguished Lecture Series continues at 11:00 a.m. February 13 with a talk by Mitchell Lazar, M.D., Ph.D., on " Nuclear Receptor Regulation of Metabolism." Lazar's talk will take place in Rodbell Auditorium and be hosted by Trevor Archer, Ph.D., chief of the NIEHS Laboratory of Molecular Carcinogenesis.

Lazar is the Sylvan H. Eisman Professor of Medicine and Genetics, chief of the Division of Endocrinology, Diabetes and Metabolism, and the director of Institute for Diabetes, Obesity and Metabolism at the University of Pennsylvania School of Medicine. He is the 2006 recipient of The Endocrine Society's Edwin B. Astwood Award.

For the past 20 years Lazar's scientific research has focused on gene and metabolic regulation and mechanisms of hormone action. His laboratory is particularly interested in receptors for small, lipophilic hormones such as thyroid hormone and retinoic acid.

Lazar also discovered the hormone resistin, which plays an integral role in insulin resistance, and his lab continues to study the molecular physiology of resistin in a number of model systems. Resistin is made only in fat cells, is secreted into the bloodstream, and reduces insulin sensitivity - making it a potential link between peroxisome proliferator activated receptor (PPAR), obesity and diabetes.

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